Leeton Shire has many well established manufacturing industries.
The processing of agricultural products from local producers comprises one of Leeton's largest industries. Ricegrowers Limited operating as SunRice and CopRice is one of the shire’s largest employers with its main office, rice mill, and manufacturing plant located in Leeton. Other major companies located within the Leeton shire include The Daily Juice Company (Bega Dairy and Drinks Pty Ltd) juice factory, JSB Australia (as a subsidiary of JBS S.A) operating a cattle feedlot and abattoirs, Stahman Webster walnut orchard and processing plant, Murrumbidgee Irrigation, Pacific Fresh Premium Australian Citrus, with Southern Cotton, Voyager Craft Malt and the Whitton Malt House located in Whitton.